Studies towards squalene synthase inhibitors: total synthesis of 6,7-dideoxysqualestatin h5 via an alkene-protection strategy
<p>The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a series of different fungi. Members of this class of highly oxygenated natural products show potent inhibitory activity against squalene synthase at the last stage of cholesterol biosynthesis,...
المؤلف الرئيسي: | Almohseni, H |
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مؤلفون آخرون: | Hodgson, D |
التنسيق: | أطروحة |
منشور في: |
2019
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مواد مشابهة
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Alkene protection against acid using a bromide substituent: application in a total synthesis of (−)-6,7-dideoxysqualestatin H5
حسب: Almohseni, H, وآخرون
منشور في: (2018) -
Total synthesis of (–)-6,7-dideoxysqualestatin H5 by carbonyl ylide cycloaddition and cross–electrophile coupling
حسب: Fegheh-Hassanpour, Y
منشور في: (2018) -
Synthesis of (−)-6,7-dideoxysqualestatin H5 by carbonyl ylide cycloaddition–rearrangement and cross-electrophile coupling
حسب: Fegheh-Hassanpour, Y, وآخرون
منشور في: (2017) -
Synthetic and computational studies on the tricarboxylate core of 6,7-dideoxysqualestatin H5 involving a carbonyl ylide cycloaddition-rearrangement.
حسب: Hodgson, D, وآخرون
منشور في: (2010) -
Accumulation of squalene in a microalga Chlamydomonas reinhardtii by genetic modification of squalene synthase and squalene epoxidase genes.
حسب: Masataka Kajikawa, وآخرون
منشور في: (2015-01-01)