Studies towards squalene synthase inhibitors: total synthesis of 6,7-dideoxysqualestatin h5 via an alkene-protection strategy

Studies towards squalene synthase inhibitors: total synthesis of 6,7-dideoxysqualestatin h5 via an alkene-protection strategy

<p>The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a series of different fungi. Members of this class of highly oxygenated natural products show potent inhibitory activity against squalene synthase at the last stage of cholesterol biosynthesis,...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Almohseni, H
Rannpháirtithe:	Hodgson, D
Formáid:	Tráchtas
Foilsithe / Cruthaithe:	2019

Míreanna comhchosúla

Alkene protection against acid using a bromide substituent: application in a total synthesis of (−)-6,7-dideoxysqualestatin H5
de réir: Almohseni, H, et al.
Foilsithe / Cruthaithe: (2018)

Total synthesis of (–)-6,7-dideoxysqualestatin H5 by carbonyl ylide cycloaddition and cross–electrophile coupling
de réir: Fegheh-Hassanpour, Y
Foilsithe / Cruthaithe: (2018)

Synthesis of (−)-6,7-dideoxysqualestatin H5 by carbonyl ylide cycloaddition–rearrangement and cross-electrophile coupling
de réir: Fegheh-Hassanpour, Y, et al.
Foilsithe / Cruthaithe: (2017)

Synthetic and computational studies on the tricarboxylate core of 6,7-dideoxysqualestatin H5 involving a carbonyl ylide cycloaddition-rearrangement.
de réir: Hodgson, D, et al.
Foilsithe / Cruthaithe: (2010)

Accumulation of squalene in a microalga Chlamydomonas reinhardtii by genetic modification of squalene synthase and squalene epoxidase genes.
de réir: Masataka Kajikawa, et al.
Foilsithe / Cruthaithe: (2015-01-01)

Alkene ozonolysis in the presence of diazo functionality: accessing an intermediate for squalestatin synthesis
de réir: Almohseni, HAA, et al.
Foilsithe / Cruthaithe: (2019)

Positive Selection of Squalene Synthase in Cucurbitaceae Plants
de réir: Jieying Qian, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-<i>Trypanosomatidae</i> Drug Discovery
de réir: Boniface Pone Kamdem, et al.
Foilsithe / Cruthaithe: (2023-08-01)

Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii
de réir: Huan Zhao, et al.
Foilsithe / Cruthaithe: (2017-03-01)

Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation
de réir: Erika Rimondi, et al.
Foilsithe / Cruthaithe: (2021-09-01)

Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes
de réir: Hironobu Hiyoshi, et al.
Foilsithe / Cruthaithe: (2003-01-01)

Squalene synthase as a target for Chagas disease therapeutics.
de réir: Na Shang, et al.
Foilsithe / Cruthaithe: (2014-05-01)

In silico analysis of Mentha pipertia (phyto-constituents) as HMG coa reductase and squalene synthase inhibitors
de réir: Narayanaswamy, Radhakrishnan, et al.
Foilsithe / Cruthaithe: (2018)

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
de réir: Dante Placido, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Correction: Squalene Synthase As a Target for Chagas Disease Therapeutics.
Foilsithe / Cruthaithe: (2014-06-01)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]
de réir: Brian M. Wasko, et al.
Foilsithe / Cruthaithe: (2011-11-01)

Introduction of a green algal squalene synthase enhances squalene accumulation in a strain of Synechocystis sp. PCC 6803
de réir: Bagmi Pattanaik, et al.
Foilsithe / Cruthaithe: (2020-06-01)

Computational study to discover potent phytochemical inhibitors against drug target, squalene synthase from Leishmania donovani
de réir: Padmika Madushanka Wadanambi, et al.
Foilsithe / Cruthaithe: (2021-06-01)

In silico analysis of squalene synthase in Fabaceae family using bioinformatics tools
de réir: Zahra Aminfar, et al.
Foilsithe / Cruthaithe: (2018-12-01)

Expression analysis of squalene synthase gene in mevalonate pathway of Sanghuangporus baumii
de réir: Shixin Wang, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Characterization of squalene synthase gene from Gymnema sylvestre R. Br.
de réir: Kuldeepsingh A. Kalariya, et al.
Foilsithe / Cruthaithe: (2021-01-01)

Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis)
de réir: Guanhua Liu, et al.
Foilsithe / Cruthaithe: (2018-12-01)

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver
de réir: Hiroaki Okazaki, et al.
Foilsithe / Cruthaithe: (2006-09-01)

Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors
de réir: Qing-Wen Zhang, et al.
Foilsithe / Cruthaithe: (2019-01-01)

Cloning, expression and purification of squalene synthase from Candida tropicalis in Pichia pastoris
de réir: Lee, Pey Yee, et al.
Foilsithe / Cruthaithe: (2014)

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.
de réir: D Amin, et al.
Foilsithe / Cruthaithe: (1992-11-01)

Squalene Cyclases and Cycloartenol Synthases from Polystichum polyblepharum and Six Allied Ferns
de réir: Junichi Shinozaki, et al.
Foilsithe / Cruthaithe: (2018-07-01)

Pharmacological effects of Artocarpus lakoocha methanol extract on inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway
de réir: Shafaq, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Overexpression of the Arabidopsis thaliana squalene synthase gene in Withania coagulans hairy root cultures
de réir: M. H. Mirjalili, et al.
Foilsithe / Cruthaithe: (2011-06-01)

Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver
de réir: Shuichi Nagashima, et al.
Foilsithe / Cruthaithe: (2015-05-01)

Cloning, Expression Analysis and Functional Characterization of Squalene Synthase (SQS) from Tripterygium wilfordii
de réir: Bin Zhang, et al.
Foilsithe / Cruthaithe: (2018-01-01)

Isolation and Characterization of Squalene Synthase Gene in Three Species of Achillea, a Rich Source of Saponins
de réir: Azra Saboora, et al.
Foilsithe / Cruthaithe: (2022-02-01)

A genomic DNA reporter screen identifies squalene synthase inhibitors which act cooperatively with statins to upregulate the low-density lipoprotein receptor
de réir: Kerr, A, et al.
Foilsithe / Cruthaithe: (2017)

Computational approach to identify potential antileishmanial activity of reported inhibitor, E5700 and two natural alkaloids against Leishmania donovani Squalene Synthase
de réir: Padmika Wadanambi, et al.
Foilsithe / Cruthaithe: (2020-01-01)

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors
de réir: Hironobu Hiyoshi, et al.
Foilsithe / Cruthaithe: (2000-07-01)

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
de réir: Lanyon-Hogg, T, et al.
Foilsithe / Cruthaithe: (2016)

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
de réir: Thomas Lanyon-Hogg, et al.
Foilsithe / Cruthaithe: (2016-06-01)

Asymmetric remote C-H borylation of internal alkenes via alkene isomerization
de réir: Xu Chen, et al.
Foilsithe / Cruthaithe: (2018-09-01)

Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
de réir: Maraswami, Manikantha, et al.
Foilsithe / Cruthaithe: (2022)

Stereodefined polymetalloid alkenes synthesis via stereoselective boron-masking of polyborylated alkenes
de réir: Nadim Eghbarieh, et al.
Foilsithe / Cruthaithe: (2023-04-01)