Studies towards squalene synthase inhibitors: total synthesis of 6,7-dideoxysqualestatin h5 via an alkene-protection strategy
<p>The zaragozic acids/squalestatins are a family of bicyclic tricarboxylic acids, isolated from a series of different fungi. Members of this class of highly oxygenated natural products show potent inhibitory activity against squalene synthase at the last stage of cholesterol biosynthesis,...
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| 格式: | Thesis |
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2019
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