Visual acuity after retinal gene therapy for Choroideremia
Two recent clinical reports of retinal gene therapy with adeno-associated virus (AAV) vectors in patients with Leber’s congenital amaurosis showed initial gains in visual function that subsequently declined. We previously reported early improvement in visual acuity in two of six patients who receive...
| Hoofdauteurs: | , , , , , , , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
Massachusetts Medical Society
2016
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| _version_ | 1826285871469428736 |
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| author | Edwards, T Jolly, J Groppe, M Barnard, A Cottriall, C Tolmachova, T Black, G Webster, A Lotery, A Holder, G Xue, K Downes, S Simunovic, M Seabra, M MacLaren, R |
| author_facet | Edwards, T Jolly, J Groppe, M Barnard, A Cottriall, C Tolmachova, T Black, G Webster, A Lotery, A Holder, G Xue, K Downes, S Simunovic, M Seabra, M MacLaren, R |
| author_sort | Edwards, T |
| collection | OXFORD |
| description | Two recent clinical reports of retinal gene therapy with adeno-associated virus (AAV) vectors in patients with Leber’s congenital amaurosis showed initial gains in visual function that subsequently declined. We previously reported early improvement in visual acuity in two of six patients who received retinal gene therapy in one eye (the study eye) to treat choroideremia, a disease that is characterized by atrophy of the choriocapillaris and retinal pigment epithelium and involves vision loss that leads to blindness. |
| first_indexed | 2024-03-07T01:35:20Z |
| format | Journal article |
| id | oxford-uuid:94f8e98a-f0bb-4106-8d86-d42cf9cba0a2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:35:20Z |
| publishDate | 2016 |
| publisher | Massachusetts Medical Society |
| record_format | dspace |
| spelling | oxford-uuid:94f8e98a-f0bb-4106-8d86-d42cf9cba0a22022-03-26T23:43:08ZVisual acuity after retinal gene therapy for ChoroideremiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:94f8e98a-f0bb-4106-8d86-d42cf9cba0a2EnglishSymplectic Elements at OxfordMassachusetts Medical Society2016Edwards, TJolly, JGroppe, MBarnard, ACottriall, CTolmachova, TBlack, GWebster, ALotery, AHolder, GXue, KDownes, SSimunovic, MSeabra, MMacLaren, RTwo recent clinical reports of retinal gene therapy with adeno-associated virus (AAV) vectors in patients with Leber’s congenital amaurosis showed initial gains in visual function that subsequently declined. We previously reported early improvement in visual acuity in two of six patients who received retinal gene therapy in one eye (the study eye) to treat choroideremia, a disease that is characterized by atrophy of the choriocapillaris and retinal pigment epithelium and involves vision loss that leads to blindness. |
| spellingShingle | Edwards, T Jolly, J Groppe, M Barnard, A Cottriall, C Tolmachova, T Black, G Webster, A Lotery, A Holder, G Xue, K Downes, S Simunovic, M Seabra, M MacLaren, R Visual acuity after retinal gene therapy for Choroideremia |
| title | Visual acuity after retinal gene therapy for Choroideremia |
| title_full | Visual acuity after retinal gene therapy for Choroideremia |
| title_fullStr | Visual acuity after retinal gene therapy for Choroideremia |
| title_full_unstemmed | Visual acuity after retinal gene therapy for Choroideremia |
| title_short | Visual acuity after retinal gene therapy for Choroideremia |
| title_sort | visual acuity after retinal gene therapy for choroideremia |
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