RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.

TLRs 7 and 8 are pattern recognition receptors controlling antiviral host defense or autoimmune diseases. Apart from foreign and host RNA, synthetic RNA oligoribonucleotides (ORN) or small molecules of the imidazoquinoline family activate TLR7 and 8 and are being developed as therapeutic agonists. T...

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Bibliographic Details
Main Authors: Colak, E, Leslie, A, Zausmer, K, Khatamzas, E, Kubarenko, A, Pichulik, T, Klimosch, SN, Mayer, A, Siggs, O, Hector, A, Fischer, R, Klesser, B, Rautanen, A, Frank, M, Hill, A, Manoury, B, Beutler, B, Hartl, D, Simmons, A, Weber, A
Format: Journal article
Language:English
Published: 2014

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