Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein.
Clustered damages are formed in DNA by ionising radiation and radiomimetic anticancer agents and are thought to be biologically severe. 7,8-dihydro-8-oxoguanine (8-oxoG), a major DNA damage resulting from oxidative attack, is highly mutagenic leading to a high level of G.C-->T.A transversions...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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