Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.
DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central roles in gene regulation. Yet how CGIs in their normal genomic context evade...
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Journal article |
| प्रकाशित: |
Oxford University Press
2016
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