Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Low-grade noninvasive papillary bladder tumors are genetically stable whereas muscle invasive bladder tumors display high levels of chromosomal aberrations. As cells deficient for nonhomologous end-joining (NHEJ) pathway components display increased genomic instability, we sought to determine the NH...

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Bibliographic Details
Main Authors: Bentley, J, L'Hôte, C, Platt, F, Hurst, C, Lowery, J, Taylor, C, Sak, S, Harnden, P, Knowles, M, Kiltie, A
Format: Journal article
Language:English
Published: 2009

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