An enantioselective Bronsted acid catalyzed enamine Mannich reaction.
An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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