Nicotine amplifies reward-related dopamine signals in striatum.
Reward-seeking behaviors depend critically on dopamine signaling--dopamine neurons encode reward-related information by switching from tonic to phasic (burst-like) activity. Using guinea pig brain slices, we show that nicotine, like cocaine and amphetamine, acts directly in striatum where it enhance...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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