Disease model distortion in association studies

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a singel nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others have...

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Bibliographic Details
Main Authors: Vukcevic, D, Hechter, E, Spencer, C, Donnelly, P
Format: Journal article
Language:English
Published: Wiley 2011
Subjects: