Interim pharmacokinetic (PK) and pharmacodynamic (PD) data from the first-in-human study of NUC-3373, a pyrimidine nucleotide analogue, in patients with advanced solid tumors

Interim pharmacokinetic (PK) and pharmacodynamic (PD) data from the first-in-human study of NUC-3373, a pyrimidine nucleotide analogue, in patients with advanced solid tumors

Библиографические подробности
Главные авторы:	Ghazaly, E, Woodcock, V, Spilipoulou, P, Spiers, L, Moschandreas, J, Griffiths, L, Gnanaranjan, C, Harrison, D, Evans, T, Blagden, S
Формат:	Conference item
Опубликовано:	Oxford University Press 2017

Схожие документы

A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301)
по: Pavlina Spiliopoulou, и др.
Опубликовано: (2024-04-01)

3373 Modulation of Hedgehog Signaling Alters Immune Infiltration in Pancreatic Cancer
по: Nina Steele, и др.
Опубликовано: (2019-03-01)

Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models
по: Longfei Zhang, и др.
Опубликовано: (2022-03-01)

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study
по: Blagden, SP, и др.
Опубликовано: (2018)

Pharmacodynamics, chiral pharmacokinetics and PK–PD modelling of ketoprofen in the goat
по: Abdul Kadir, Arifah, и др.
Опубликовано: (2003)

Pharmacodynamics, chiral pharmacokinetics and PK-PD modelling of ketoprofen in the goat
по: A. K., Arifah, и др.
Опубликовано: (2003)

Using Nucs in Beekeeping Operations
по: J. D. Ellis
Опубликовано: (2019-09-01)

Using Nucs in Beekeeping Operations
по: J. D. Ellis
Опубликовано: (2019-09-01)

Using Nucs in Beekeeping Operations
по: J. D. Ellis
Опубликовано: (2019-09-01)

Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors
по: Liudmila A. Alexandrova, и др.
Опубликовано: (2022-06-01)

Editorial: Pharmacokinetics, pharmacodynamics (PK/PD) of antibiotics: A reality check
по: Markus Zeitlinger, и др.
Опубликовано: (2023-02-01)

In vivo Pharmacokinetic and Pharmacodynamic (PK/PD) Modeling and Establishment of the PK/PD Cutoff of Florfenicol Against Pasteurella multocida in Ducks
по: Xia Xiao, и др.
Опубликовано: (2021-01-01)

Pyrimidine analogues for the management of neurodegenerative diseases
по: Swati Pant, и др.
Опубликовано: (2022-12-01)

Purine and pyrimidine nucleotide metabolism in Mollicutes
по: Cristiano Valim Bizarro, и др.
Опубликовано: (2007-01-01)

The Advantages of Using Nucs in Beekeeping Operations
по: James D. Ellis, и др.
Опубликовано: (2010-10-01)

The Advantages of Using Nucs in Beekeeping Operations
по: James D. Ellis, и др.
Опубликовано: (2010-10-01)

The Advantages of Using Nucs in Beekeeping Operations
по: James D. Ellis, и др.
Опубликовано: (2010-10-01)

Some aspects of pyrimidine nucleotide synthesis in excised pea plants
по: L. D. Wasilewska, и др.
Опубликовано: (2015-01-01)

Pulse Drug Delivery Strategy Based on Pharmacokinetic-Pharmacodynamic (PK-PD) Model of Tolerance
по: Jiali Ai, и др.
Опубликовано: (2022-09-01)

Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs
по: Zhixin Lei, и др.
Опубликовано: (2017-08-01)

Photophysical Deactivation Mechanisms of the Pyrimidine Analogue 1-Cyclohexyluracil
по: Danillo Valverde, и др.
Опубликовано: (2021-08-01)

Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides
по: Anton V. Endutkin, и др.
Опубликовано: (2024-06-01)

The Effects of Addition of Mononucleotides on Sma nuc Endonuclease Activity
по: Julia Romanova, и др.
Опубликовано: (2012-01-01)

Genetic identification for Staphylococcus aureus by using nuc gene
по: Mushtaq T. Salih, и др.
Опубликовано: (2015-12-01)

Inter-individual variability in propofol pharmacokinetic/pharmacodynamic (PK/PD) model – a sensitivity analysis
по: Chang, J. J., и др.
Опубликовано: (2016)

Pharmacodynamic Target Assessment and PK/PD Cutoff Determination for Gamithromycin Against Streptococcus suis in Piglets
по: Rui-Ling Wang, и др.
Опубликовано: (2022-07-01)

Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim.
по: Kuyper, L, и др.
Опубликовано: (1996)

Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant <i>Staphylococcus aureus</i>
по: Katharina Rox, и др.
Опубликовано: (2022-12-01)

Chinese ICU physicians’ knowledge of antibiotic pharmacokinetics/pharmacodynamics (PK/PD): a cross-sectional survey
по: Wenchao Mao, и др.
Опубликовано: (2022-03-01)

An Energy-Domain IR NUC Method Based on Unsupervised Learning
по: Ting Li, и др.
Опубликовано: (2025-01-01)

NucGame: um jogo didático sobre Tecnologia Nuclear
по: Luana Linda da Silva, и др.
Опубликовано: (2023-05-01)

NucBase, an easy to use read mapper for small RNAs
по: Dufourt Jeremy, и др.
Опубликовано: (2013-01-01)

Design, Synthesis, Pharmacodynamic and <i>In Silico</i> Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers
по: Ahmed M. Farghaly, и др.
Опубликовано: (2022-03-01)

Synthesis of Chiral Acyclic Pyrimidine Nucleoside Analogues from DHAP-Dependent Aldolases
по: Mariano Nigro, и др.
Опубликовано: (2024-06-01)

Replication of cyclobutane pyrimidine dimer analogue by Ex Taq DNA polymerase
по: Masayuki Ogino et al
Опубликовано: (2007-01-01)

Synthesis of Cyclic and Acyclic Pyrimidine Nucleosides Analogues with Anticipated Antiviral Activity
по: Mohamed El-Shehry, и др.
Опубликовано: (2018-06-01)

Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease.
по: Megan R Kiedrowski, и др.
Опубликовано: (2014-01-01)

The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model
по: Nan Xu, и др.
Опубликовано: (2024-01-01)

A Population Pharmacokinetic (Pk)- Pharmacodynamic (Pd) Analysis Of Peginesatide India Lysis Patients With Chronic Kidney Disease
по: Himanshu Naik, и др.
Опубликовано: (2012-06-01)

Pharmacokinetic/pharmacodynamic (PK/PD) evaluation of tulathromycin against Haemophilus parasuis in an experimental neutropenic guinea pig model.
по: Yongda Zhao, и др.
Опубликовано: (2018-01-01)