Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and...

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Bibliographic Details
Main Authors:	Fisher, SA, Tremelling, M, Anderson, C, Gwilliam, R, Bumpstead, S, Prescott, N, Nimmo, E, Massey, D, Berzuini, C, Johnson, C, Barrett, J, Cummings, F, Drummond, H, Lees, C, Onnie, C, Hanson, C, Blaszczyk, K, Inouye, M, Ewels, P, Ravindrarajah, R, Keniry, A, Hunt, S, Carter, M, Watkins, N, Ouwehand, W, Lewis, C, Cardon, L, Lobo, A, Forbes, A, Sanderson, J, Jewell, D, Mansfield, J, Deloukas, P, Mathew, C, Parkes, M, Satsangi, J
Format:	Journal article
Language:	English
Published:	2008

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

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