Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that incre...

书目详细资料
Main Authors:	Jaeger, E, Webb, E, Howarth, K, Carvajal-Carmona, L, Rowan, A, Broderick, P, Walther, A, Spain, S, Pittman, A, Kemp, Z, Sullivan, K, Heinimann, K, Lubbe, S, Domingo, E, Barclay, E, Martin, L, Gorman, M, Chandler, I, Vijayakrishnan, J, Wood, W, Papaemmanuil, E, Penegar, S, Qureshi, M, Farrington, S, Tenesa, A
格式:	Journal article
语言:	English
出版:	2008

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