p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation.

AU-rich elements (AREs) in 3'-untranslated regions of mRNAs confer instability. They target mRNAs for rapid deadenylation and degradation and may enhance decapping. The p38 MAPK pathway stabilizes many otherwise unstable ARE-containing mRNAs encoding proteins involved in inflammation; however,...

詳細記述

書誌詳細
主要な著者: Dean, J, Sarsfield, S, Tsounakou, E, Saklatvala, J
フォーマット: Journal article
言語:English
出版事項: 2003