Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Sulphonylurea drugs are the therapy of choice for treating neonatal diabetes (ND) caused by mutations in the ATP-sensitive K(+) channel (KATP channel). We investigated the interactions between MgATP, MgADP, and the sulphonylurea gliclazide with KATP channels expressed in Xenopus oocytes. In the abse...

Bibliográfalaš dieđut
Váldodahkkit:	Proks, P, De Wet, H, Ashcroft, F
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2013

Geahča maid

Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.
Dahkki: Proks, P, et al.
Almmustuhtton: (1997)

Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
Dahkki: Gribble, F, et al.
Almmustuhtton: (1998)

How ATP inhibits the open K(ATP) channel.
Dahkki: Craig, T, et al.
Almmustuhtton: (2008)

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
Dahkki: Reimann, F, et al.
Almmustuhtton: (2003)

Mechanism of K-ATP channel inhibition by ATP
Dahkki: Ashcroft, F, et al.
Almmustuhtton: (1998)

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
Dahkki: Trapp, S, et al.
Almmustuhtton: (1998)

The extent of K-ATP channel block by MgATP correlates with the clinical phenotype caused by gain-of-function KCNJ11 mutations
Dahkki: Proks, R, et al.
Almmustuhtton: (2005)

Inhibition of cloned K-ATP channels by stilbene disulphonates
Dahkki: Proks, P, et al.
Almmustuhtton: (2000)

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
Dahkki: Proks, P, et al.
Almmustuhtton: (2010)

High-affinity block of K-ATP channels of mouse isolated pancreatic beta-cells but not rat heart or arterial smooth muscle cells by the sulphonylurea gliclazide
Dahkki: Jones, P, et al.
Almmustuhtton: (2001)

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
Dahkki: Tucker, S, et al.
Almmustuhtton: (1997)

Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel
Dahkki: Trapp, S, et al.
Almmustuhtton: (1998)

Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor
Dahkki: Peter Proks
Almmustuhtton: (2013-06-01)

Modeling K(ATP) channel gating and its regulation.
Dahkki: Proks, P, et al.
Almmustuhtton: (2009)

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
Dahkki: Bokvist, K, et al.
Almmustuhtton: (1999)

Inhibition of ATP-sensitive potassium channels by haloperidol.
Dahkki: Yang, S, et al.
Almmustuhtton: (2004)

Modification of K-ATP channels in pancreatic beta-cells by trypsin.
Dahkki: Proks, P, et al.
Almmustuhtton: (1993)

Interaction of stilbene disulphonates with cloned K(ATP) channels.
Dahkki: Proks, P, et al.
Almmustuhtton: (2001)

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.
Dahkki: Proks, P, et al.
Almmustuhtton: (2005)

Interaction of vanadate with the cloned beta cell K(ATP) channel.
Dahkki: Proks, P, et al.
Almmustuhtton: (1999)

Modulation of gating of the cloned beta-cell K-ATP channel
Dahkki: Proks, P, et al.
Almmustuhtton: (1998)

Dynamic sensitivity of K-ATP channels to ATP
Dahkki: Loussouarn, G, et al.
Almmustuhtton: (2001)

EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
Dahkki: Proks, P, et al.
Almmustuhtton: (1992)

Molecular determinants of KATP channel inhibition by ATP.
Dahkki: Tucker, S, et al.
Almmustuhtton: (1998)

Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
Dahkki: Mikhailov, M, et al.
Almmustuhtton: (1998)

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.
Dahkki: Loussouarn, G, et al.
Almmustuhtton: (2001)

A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M
Dahkki: Girard, C, et al.
Almmustuhtton: (2008)

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
Dahkki: Tanabe, K, et al.
Almmustuhtton: (1999)

The Yin and Yang of the K(ATP) channel.
Dahkki: Ashcroft, F
Almmustuhtton: (2000)

THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS
Dahkki: Proks, P, et al.
Almmustuhtton: (1993)

Two types of gating in inward rectifiers: The case of the K-ATP channel.
Dahkki: Proks, P, et al.
Almmustuhtton: (2001)

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
Dahkki: Trapp, S, et al.
Almmustuhtton: (1998)

Properties and functions of ATP-sensitive K-channels.
Dahkki: Ashcroft, S, et al.
Almmustuhtton: (1990)

Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones.
Dahkki: Röper, J, et al.
Almmustuhtton: (1995)

Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
Dahkki: Proks, P, et al.
Almmustuhtton: (1994)

THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS
Dahkki: Proks, P, et al.
Almmustuhtton: (1993)

Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.
Dahkki: Clark, R, et al.
Almmustuhtton: (2012)

Mice expressing a human K ATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities
Dahkki: Clark, R, et al.
Almmustuhtton: (2012)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
Dahkki: Proks, P, et al.
Almmustuhtton: (1999)

Differential metabolic and nucleotide sensitivity of beta-cell and cardiac K-ATP channels
Dahkki: Vedovato, N, et al.
Almmustuhtton: (2018)