DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell sur...

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Detalhes bibliográficos
Main Authors:	Randall, K, Chan, S, Ma, C, Fung, I, Mei, Y, Yabas, M, Tan, A, Arkwright, P, Al Suwairi, W, Lugo Reyes, S, Yamazaki-Nakashimada, M, Garcia-Cruz, M, Smart, J, Picard, C, Okada, S, Jouanguy, E, Casanova, J, Lambe, T, Cornall, R, Russell, S, Oliaro, J, Tangye, S, Bertram, E, Goodnow, C
Formato:	Journal article
Idioma:	English
Publicado em:	2011

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.

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