Fumarate hydratase deficiency and cancer: activation of hypoxia signaling?

Fumarate hydratase deficiency and cancer: activation of hypoxia signaling?

Molecular genetic analysis of hereditary leiomyomatosis and renal cell cancer (HLRCC) unexpectedly revealed germline defects in the gene encoding the Krebs cycle enzyme fumarate hydratase (FH), stimulating great interest in the underlying mechanism of oncogenesis. It has been proposed that the assoc...

書誌詳細
第一著者:	Ratcliffe, P
フォーマット:	Journal article
言語:	English
出版事項:	2007

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