Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.

Terminating transcription is a highly intricate process for mammalian protein-coding genes. First, the chromatin template slows down transcription at the gene end. Then, the transcript is cleaved at the poly(A) signal to release the messenger RNA.The remaining transcript is selectively unraveled and...

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Autore principale: Proudfoot, N
Natura: Journal article
Lingua:English
Pubblicazione: American Association for the Advancement of Science 2016