Structures of the RNA-guided surveillance complex from a bacterial immune system.

Bacteria and archaea acquire resistance to viruses and plasmids by integrating short fragments of foreign DNA into clustered regularly interspaced short palindromic repeats (CRISPRs). These repetitive loci maintain a genetic record of all prior encounters with foreign transgressors. CRISPRs are tran...

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Bibliographic Details
Main Authors: Wiedenheft, B, Lander, G, Zhou, K, Jore, M, Brouns, S, van der Oost, J, Doudna, J, Nogales, E
Format: Journal article
Language:English
Published: 2011