Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.

Fluoride assays for oxygenases: The 2-oxoglutarate-dependent oxygenase BBOX catalyses the final step in carnitine biosynthesis and is a medicinal chemistry target. We report that BBOX can hydroxylate fluorinated substrates analogues with subsequent release of a fluoride ion, thereby enabling an effi...

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Bibliografische gegevens
Hoofdauteurs: Rydzik, A, Leung, I, Kochan, G, Thalhammer, A, Oppermann, U, Claridge, T, Schofield, C
Formaat: Journal article
Taal:English
Gepubliceerd in: 2012