Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves

Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs)...

Повний опис

Бібліографічні деталі
Автори: Zhang, J, Shrivastava, S, Cleveland, R, Rabbitts, T
Формат: Journal article
Мова:English
Опубліковано: American Chemical Society 2019