Regulation of calcium in pancreatic α- and β-cells in health and disease.

The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exo...

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Main Authors: Rorsman, P, Braun, M, Zhang, Q
Formato: Journal article
Idioma:English
Publicado em: 2012
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author Rorsman, P
Braun, M
Zhang, Q
author_facet Rorsman, P
Braun, M
Zhang, Q
author_sort Rorsman, P
collection OXFORD
description The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes.
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spelling oxford-uuid:975194b9-cb4c-41be-8f7b-bc8054eb6c112022-03-26T23:58:35ZRegulation of calcium in pancreatic α- and β-cells in health and disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:975194b9-cb4c-41be-8f7b-bc8054eb6c11EnglishSymplectic Elements at Oxford2012Rorsman, PBraun, MZhang, QThe glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes.
spellingShingle Rorsman, P
Braun, M
Zhang, Q
Regulation of calcium in pancreatic α- and β-cells in health and disease.
title Regulation of calcium in pancreatic α- and β-cells in health and disease.
title_full Regulation of calcium in pancreatic α- and β-cells in health and disease.
title_fullStr Regulation of calcium in pancreatic α- and β-cells in health and disease.
title_full_unstemmed Regulation of calcium in pancreatic α- and β-cells in health and disease.
title_short Regulation of calcium in pancreatic α- and β-cells in health and disease.
title_sort regulation of calcium in pancreatic α and β cells in health and disease
work_keys_str_mv AT rorsmanp regulationofcalciuminpancreaticaandbcellsinhealthanddisease
AT braunm regulationofcalciuminpancreaticaandbcellsinhealthanddisease
AT zhangq regulationofcalciuminpancreaticaandbcellsinhealthanddisease