Regulation of calcium in pancreatic α- and β-cells in health and disease.
The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exo...
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826286345306243072 |
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| author | Rorsman, P Braun, M Zhang, Q |
| author_facet | Rorsman, P Braun, M Zhang, Q |
| author_sort | Rorsman, P |
| collection | OXFORD |
| description | The glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes. |
| first_indexed | 2024-03-07T01:42:22Z |
| format | Journal article |
| id | oxford-uuid:975194b9-cb4c-41be-8f7b-bc8054eb6c11 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:42:22Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:975194b9-cb4c-41be-8f7b-bc8054eb6c112022-03-26T23:58:35ZRegulation of calcium in pancreatic α- and β-cells in health and disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:975194b9-cb4c-41be-8f7b-bc8054eb6c11EnglishSymplectic Elements at Oxford2012Rorsman, PBraun, MZhang, QThe glucoregulatory hormones insulin and glucagon are released from the β- and α-cells of the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials, Ca(2+)-influx via voltage-gated Ca(2+)-channels, elevation of [Ca(2+)](i) and initiation of Ca(2+)-dependent exocytosis. Here we discuss the mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose, the roles played by different types of voltage-gated Ca(2+)-channel present in α- and β-cells and the modulation of hormone secretion by Ca(2+)-dependent and -independent processes. We also consider how subtle changes in Ca(2+)-signalling may have profound impact on β-cell performance and increase risk of developing type-2 diabetes. |
| spellingShingle | Rorsman, P Braun, M Zhang, Q Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title | Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title_full | Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title_fullStr | Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title_full_unstemmed | Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title_short | Regulation of calcium in pancreatic α- and β-cells in health and disease. |
| title_sort | regulation of calcium in pancreatic α and β cells in health and disease |
| work_keys_str_mv | AT rorsmanp regulationofcalciuminpancreaticaandbcellsinhealthanddisease AT braunm regulationofcalciuminpancreaticaandbcellsinhealthanddisease AT zhangq regulationofcalciuminpancreaticaandbcellsinhealthanddisease |