RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Chemokine signalling drives monocyte recruitment in atherosclerosis and aortic aneurysms. The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to s...

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Bibliographic Details
Main Authors: Patel, J, McNeill, E, Douglas, G, Hale, A, de Bono, J, Lee, R, Iqbal, A, Regan-Komito, D, Stylianou, E, Greaves, D, Channon, K
Format: Journal article
Language:English
Published: Nature Publishing Group 2015