RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling
Chemokine signalling drives monocyte recruitment in atherosclerosis and aortic aneurysms. The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to s...
| Main Authors: | , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Nature Publishing Group
2015
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| _version_ | 1826286372393058304 |
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| author | Patel, J McNeill, E Douglas, G Hale, A de Bono, J Lee, R Iqbal, A Regan-Komito, D Stylianou, E Greaves, D Channon, K |
| author_facet | Patel, J McNeill, E Douglas, G Hale, A de Bono, J Lee, R Iqbal, A Regan-Komito, D Stylianou, E Greaves, D Channon, K |
| author_sort | Patel, J |
| collection | OXFORD |
| description | Chemokine signalling drives monocyte recruitment in atherosclerosis and aortic aneurysms. The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to sustained chemokine stimulation. Here we show that Rgs1 is upregulated in atherosclerotic plaque and aortic aneurysms. Rgs1 reduces macrophage chemotaxis and desensitizes chemokine receptor signalling. In early atherosclerotic lesions, Rgs1 regulates macrophage accumulation and is required for the formation and rupture of Angiotensin II-induced aortic aneurysms, through effects on leukocyte retention. Collectively, these data reveal a role for Rgs1 in leukocyte trafficking and vascular inflammation and identify Rgs1, and inhibition of chemokine receptor signalling as potential therapeutic targets in vascular disease. |
| first_indexed | 2024-03-07T01:42:46Z |
| format | Journal article |
| id | oxford-uuid:976c8bfe-97d8-45e8-b024-b659a28b4b02 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:42:46Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:976c8bfe-97d8-45e8-b024-b659a28b4b022022-03-26T23:59:36ZRGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signallingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:976c8bfe-97d8-45e8-b024-b659a28b4b02EnglishSymplectic Elements at OxfordNature Publishing Group2015Patel, JMcNeill, EDouglas, GHale, Ade Bono, JLee, RIqbal, ARegan-Komito, DStylianou, EGreaves, DChannon, KChemokine signalling drives monocyte recruitment in atherosclerosis and aortic aneurysms. The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to sustained chemokine stimulation. Here we show that Rgs1 is upregulated in atherosclerotic plaque and aortic aneurysms. Rgs1 reduces macrophage chemotaxis and desensitizes chemokine receptor signalling. In early atherosclerotic lesions, Rgs1 regulates macrophage accumulation and is required for the formation and rupture of Angiotensin II-induced aortic aneurysms, through effects on leukocyte retention. Collectively, these data reveal a role for Rgs1 in leukocyte trafficking and vascular inflammation and identify Rgs1, and inhibition of chemokine receptor signalling as potential therapeutic targets in vascular disease. |
| spellingShingle | Patel, J McNeill, E Douglas, G Hale, A de Bono, J Lee, R Iqbal, A Regan-Komito, D Stylianou, E Greaves, D Channon, K RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title_full | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title_fullStr | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title_full_unstemmed | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title_short | RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
| title_sort | rgs1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling |
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