Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and mice

Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-determining regions (CDRs) of more than 180 millio...

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Bibliographic Details
Main Authors: Kovaltsuk, A, Raybould, MIJ, Wong, WK, Marks, C, Kelm, S, Snowden, J, Trück, J, Deane, CM
Format: Journal article
Language:English
Published: Public Library of Science 2020