Role of R-loops in pause-dependent transcriptional termination of RNA polymerase II
Transcription termination of RNA polymerase II (Pol II) in mammals requires a functional poly(A) signal and either downstream pause sites or co-transcriptional cleavage (CoTC) sequences together with 3’transcript degradation by the nuclear 5’-3’ exonuclease Xrn2. However the molecular mechanism of p...
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| Format: | Thesis |
| Language: | English |
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2012
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