Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).

Faecal urgency and incontinence with rectal hypersensitivity is a chronic, unexplained condition that is difficult to treat. The aim of this study was to determine if there was an altered level of the voltage gated tetrodotoxin-sensitive (TTX-s) sodium channel Na(v)1.7 in rectal sensory fibres, sinc...

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Detalles Bibliográficos
Autores principales: Yiangou, Y, Facer, P, Chessell, I, Bountra, C, Chan, C, Fertleman, C, Smith, V, Anand, P
Formato: Journal article
Lenguaje:English
Publicado: 2007