Lck and the nature of the T cell receptor trigger.

Lck and the nature of the T cell receptor trigger.

Εμφάνιση άλλων εκδόσεων (1)

Exactly how ligand binding 'triggers' T cell receptor (TCR) phosphorylation is unclear. It has been proposed that ligand engagement by the TCR somehow activates the Src kinase Lck, which in turn phosphorylates the receptor. Recent data, however, suggest instead that a significant fraction...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Davis, S, Van Der Merwe, P
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2011

Παρόμοια τεκμήρια

Lck and the nature of the T cell receptor trigger
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TCR triggering induces the formation of Lck-RACK1-actinin-1 multiprotein network affecting Lck redistribution
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Mechanisms for T cell receptor triggering.
ανά: Van Der Merwe, P, κ.ά.
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TCR triggering: co-receptor-dependent or -independent?
ανά: Davis, S, κ.ά.
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Molecular mechanisms involved in T cell receptor triggering.
ανά: Choudhuri, K, κ.ά.
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Molecular mechanisms involved in T cell receptor triggering
ανά: Choudhuri, K, κ.ά.
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CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
ανά: Irles, C, κ.ά.
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Lck, membrane microdomains and TCR triggering machinery: defining the new rules of engagement
ανά: Dominik eFilipp, κ.ά.
Έκδοση: (2012-06-01)

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
ανά: Nika, K, κ.ά.
Έκδοση: (2010)

The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.
ανά: Thome, M, κ.ά.
Έκδοση: (1996)

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
ανά: Hee-Don Chae, κ.ά.
Έκδοση: (2010-11-01)

CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.
ανά: Arcaro, A, κ.ά.
Έκδοση: (2001)

CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation
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Ectopic Lck expression in CLL demarcates intratumoral subpopulations with aberrant B-cell receptor signaling
ανά: Efthymia Theofani, κ.ά.
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TCR triggering: Co-receptor-dependent or -independent? [2] (multiple letters)
ανά: Davis, S, κ.ά.
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Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
ανά: I-Tsu Chyuan, κ.ά.
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The kinetic-segregation model: TCR triggering and beyond.
ανά: Davis, S, κ.ά.
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The kinetic-segregation model: TCR triggering and beyond
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Distinct mechanisms regulate Lck spatial organization in activated T cells
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Έκδοση: (2016)

Distinct mechanisms regulate Lck spatial organization in activated T cells
ανά: Natasha eKapoor-Kaushik, κ.ά.
Έκδοση: (2016-03-01)

On LCK solvmanifolds with a property of Vaisman solvmanifolds
ανά: Sawai Hiroshi
Έκδοση: (2022-07-01)

Example of a six-dimensional LCK solvmanifold
ανά: Sawai Hiroshi
Έκδοση: (2017-02-01)

LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target
ανά: Ying Cheng, κ.ά.
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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.
ανά: Choudhuri, K, κ.ά.
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The immunological synapse: required for T cell receptor signalling or directing T cell effector function?
ανά: Davis, S, κ.ά.
Έκδοση: (2001)

The immunological synapse: required for T cell receptor signalling or directing T cell effector function?
ανά: Davis, S, κ.ά.
Έκδοση: (2001)

Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor
ανά: Jiatao Zhou, κ.ά.
Έκδοση: (2021-06-01)

The TCR triggering puzzle.
ανά: Van Der Merwe, P
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A systematic investigation on the mechanism of non-catalytic tyrosine phosphorylated receptor triggering
ανά: Denham, E, κ.ά.
Έκδοση: (2014)

Compact lcK manifolds with parallel vector fields
ανά: Moroianu Andrei
Έκδοση: (2015-07-01)

Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.
ανά: Thome, M, κ.ά.
Έκδοση: (1995)

The Lck Paradox: Because of Inconsistent Experimental Evidence, the Role of the Protein Tyrosine Kinase p56lck in Early Thymic Development Remains Poorly Defined
ανά: Klaus Eichmann
Έκδοση: (1998-01-01)

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
ανά: Frederike A. Hartl, κ.ά.
Έκδοση: (2021-04-01)

New insights into the Lck-NF-κB signaling pathway
ανά: Jing Zhang, κ.ά.
Έκδοση: (2023-02-01)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
ανά: Bird Ian N, κ.ά.
Έκδοση: (2011-01-01)

INTERACTION OF SYK AND ZAP-70 WITH P56LCK/CD4
ανά: Acuto, O, κ.ά.
Έκδοση: (1995)

Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
ανά: Kumiko Nakahira, κ.ά.
Έκδοση: (2013-01-01)

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
ανά: Davis, M. M., κ.ά.
Έκδοση: (2017)

Do T cell receptors do it alone?
ανά: Van Der Merwe, P
Έκδοση: (2002)

CD2 and the nature of protein interactions mediating cell-cell recognition.
ανά: Davis, S, κ.ά.
Έκδοση: (1998)