Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.

The reaction of enol(ate)s with electrophiles is used extensively in organic synthesis for stereoselective C-C bond formation. Protein-based catalysts have had comparatively limited application for the stereoselective formation of C-C bonds of choice via enolate chemistry. We describe protein engine...

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Hlavní autoři: Hamed, R, Gomez-Castellanos, JR, Thalhammer, A, Harding, D, Ducho, C, Claridge, T, Schofield, C
Médium: Journal article
Jazyk:English
Vydáno: 2011