CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

CD161(++) CD8(+) T cells represent a novel subset that is dominated in adult peripheral blood by mucosal-associated invariant T (MAIT) cells, as defined by the expression of a variable-α chain 7.2 (Vα7.2)-Jα33 TCR, and IL-18Rα. Stimulation with IL-18+IL-12 is known to induce IFN-γ by both NK cells a...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Ussher, J, Bilton, M, Attwod, E, Shadwell, J, Richardson, R, de Lara, C, Mettke, E, Kurioka, A, Hansen, T, Klenerman, P, Willberg, C
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	2014

Míreanna comhchosúla

CD161(++)CD8(+) T cells express IFNgamma in response to TLR8 stimulation in an IL-12(+) IL-18 dependent, TCR independent, manner
de réir: Willberg, C, et al.
Foilsithe / Cruthaithe: (2012)

Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.
de réir: Cosgrove, C, et al.
Foilsithe / Cruthaithe: (2013)

A novel model of MHC class I-related (MR1)-mediated activation of MAIT cells
de réir: Ussher, J, et al.
Foilsithe / Cruthaithe: (2012)

Shared and distinct phenotypes and functions of human CD161++ Vα7.2+ T cell subsets
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2017)

A novel subset of anti-viral T cells: the CD161dim CD8(+) population
de réir: Fergusson, JR, et al.
Foilsithe / Cruthaithe: (2012)

MAIT cells (TCR7.2+CD161++CD8+) are functionally impaired during chronic SHIV infection
de réir: A. Murugesan, et al.
Foilsithe / Cruthaithe: (2020-12-01)

MAIT cells and viruses
de réir: Ussher, JE, et al.
Foilsithe / Cruthaithe: (2018)

Impact of cross-linking CD161 on human T cells
de réir: Smith, K, et al.
Foilsithe / Cruthaithe: (2012)

MAIT cells: new guardians of the liver
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2016)

Erratum: MAIT cells: new guardians of the liver.
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2017)

CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2018)

CD161int CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut
de réir: Klenerman, P, et al.
Foilsithe / Cruthaithe: (2015)

Mucosal-associated invariant T (MAIT) cells: new players in anti-bacterial immunity
de réir: James E Ussher, et al.
Foilsithe / Cruthaithe: (2014-10-01)

CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ.
de réir: Kang, Y, et al.
Foilsithe / Cruthaithe: (2012)

Association between impaired vα7.2+cd161++cd8+ (MAIT) and vα7.2+cd161-cd8+ t-cell populations and gut dysbiosis in chronically HIV-and/or HCV-infected patients
de réir: Merlini, E, et al.
Foilsithe / Cruthaithe: (2019)

CD161 expressing human T cells
de réir: Joannah R Fergusson, et al.
Foilsithe / Cruthaithe: (2011-08-01)

Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection
de réir: Wong, E, et al.
Foilsithe / Cruthaithe: (2013)

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection
de réir: Wong, E, et al.
Foilsithe / Cruthaithe: (2013)

Mucosal associated invariant T cells and CD161 expressing natural killer cells
de réir: Kurioka, A
Foilsithe / Cruthaithe: (2015)

Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients
de réir: Esther Merlini, et al.
Foilsithe / Cruthaithe: (2019-08-01)

Attrition of TCR Vα7.2+ CD161++ MAIT cells in HIV-tuberculosis co-infection is associated with elevated levels of PD-1 expression.
de réir: Alireza Saeidi, et al.
Foilsithe / Cruthaithe: (2015-01-01)

CD161-expressing human T cells.
de réir: Fergusson, JR, et al.
Foilsithe / Cruthaithe: (2011)

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.
de réir: Emily B Wong, et al.
Foilsithe / Cruthaithe: (2013-01-01)

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2018)

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile
de réir: Kathleen M. Wragg, et al.
Foilsithe / Cruthaithe: (2020-06-01)

CD161+CD4+ T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and Interferon-gamma
de réir: Yu-Hoi eKang, et al.
Foilsithe / Cruthaithe: (2012-11-01)

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2015)

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells
de réir: Ussher, J, et al.
Foilsithe / Cruthaithe: (2016)

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
de réir: Billerbeck, E, et al.
Foilsithe / Cruthaithe: (2010)

MAIT cells induce proinflammatory cytokine production in monocytes through the secretion of granzymes A and K
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2012)

MAIT cells induce proinflammatory cytokine production in monocytes through the secretion of granzymes A and K
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2011)

Biological functions of MAIT cells in tissues
de réir: Klenerman, P, et al.
Foilsithe / Cruthaithe: (2020)

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells
de réir: Ayako Kurioka, et al.
Foilsithe / Cruthaithe: (2018-04-01)

CD161 expression defines new human γδ T cell subsets
de réir: Amali Karunathilaka, et al.
Foilsithe / Cruthaithe: (2022-02-01)

High MDR‐1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR‐1 substrates
de réir: Fergusson, JR, et al.
Foilsithe / Cruthaithe: (2018)

Changes in the Vα7.2+ CD161++ MAIT cell compartment in early pregnancy are associated with preterm birth in HIV-positive women
de réir: Ravi, K, et al.
Foilsithe / Cruthaithe: (2020)

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.
de réir: Fergusson, JR, et al.
Foilsithe / Cruthaithe: (2014)

CD161 expression defines a phenotypically, functionally and transcriptionally distinct set of NK cells which are specifically depleted in HIV infection
de réir: Kurioka, A, et al.
Foilsithe / Cruthaithe: (2012)

Human MAIT cell activation in vitro
de réir: Hagel, JP, et al.
Foilsithe / Cruthaithe: (2019)

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions
de réir: Leng, T, et al.
Foilsithe / Cruthaithe: (2019)