Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH2i) is associated with the viral mimicry response. Unlike o...

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Bibliographic Details
Main Authors:	Feng, S, Marhon, SA, Sokolowski, DJ, D’Costa, A, Soares, F, Mehdipour, P, Ishak, C, Loo Yau, H, Ettayebi, I, Patel, PS, Chen, R, Liu, J, Zuzarte, PC, Ho, KC, Ho, B, Ning, S, Huang, A, Arrowsmith, CH, Wilson, MD, Simpson, JT, De Carvalho, DD
Format:	Journal article
Language:	English
Published:	Nature Research 2024

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

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