Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

In humans, polyadenylation of messenger RNA (mRNA) protects transcripts from degradation and enhances translation efficiency. Conversely, in bacteria, polyadenylation destabilizes mRNA. RNA adenylation was recently implicated in promoting degradation of some yeast RNAs by the exosome. The exosome co...

書誌詳細
主要な著者:	West, S, Gromak, N, Norbury, C, Proudfoot, N
フォーマット:	Journal article
言語:	English
出版事項:	2006

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