Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.

In humans, polyadenylation of messenger RNA (mRNA) protects transcripts from degradation and enhances translation efficiency. Conversely, in bacteria, polyadenylation destabilizes mRNA. RNA adenylation was recently implicated in promoting degradation of some yeast RNAs by the exosome. The exosome co...

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Detalhes bibliográficos
Main Authors:	West, S, Gromak, N, Norbury, C, Proudfoot, N
Formato:	Journal article
Idioma:	English
Publicado em:	2006

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