Single-nucleotide polymorphisms in the p53 signaling pathway.
The p53 tumor suppressor pathway is central both in reducing cancer frequency in vertebrates and in mediating the response of commonly used cancer therapies. This article aims to summarize and discuss a large body of evidence suggesting that the p53 pathway harbors functional inherited single-nucleo...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826286574205140992 |
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| author | Grochola, L Zeron-Medina, J Mériaux, S Bond, G |
| author_facet | Grochola, L Zeron-Medina, J Mériaux, S Bond, G |
| author_sort | Grochola, L |
| collection | OXFORD |
| description | The p53 tumor suppressor pathway is central both in reducing cancer frequency in vertebrates and in mediating the response of commonly used cancer therapies. This article aims to summarize and discuss a large body of evidence suggesting that the p53 pathway harbors functional inherited single-nucleotide polymorphisms (SNPs) that affect p53 signaling in cells, resulting in differences in cancer risk and clinical outcome in humans. The insights gained through these studies into how the functional p53 pathway SNPs could help in the tailoring of cancer therapies to the individual are discussed. Moreover, recent work is discussed that suggests that many more functional p53 pathway SNPs are yet to be fully characterized and that a thorough analysis of the functional human genetics of this important tumor suppressor pathway is required. |
| first_indexed | 2024-03-07T01:45:45Z |
| format | Journal article |
| id | oxford-uuid:985e1e0c-5f2b-47f6-b3ef-5349b81e54d9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:45:45Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:985e1e0c-5f2b-47f6-b3ef-5349b81e54d92022-03-27T00:06:21ZSingle-nucleotide polymorphisms in the p53 signaling pathway.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:985e1e0c-5f2b-47f6-b3ef-5349b81e54d9EnglishSymplectic Elements at Oxford2010Grochola, LZeron-Medina, JMériaux, SBond, GThe p53 tumor suppressor pathway is central both in reducing cancer frequency in vertebrates and in mediating the response of commonly used cancer therapies. This article aims to summarize and discuss a large body of evidence suggesting that the p53 pathway harbors functional inherited single-nucleotide polymorphisms (SNPs) that affect p53 signaling in cells, resulting in differences in cancer risk and clinical outcome in humans. The insights gained through these studies into how the functional p53 pathway SNPs could help in the tailoring of cancer therapies to the individual are discussed. Moreover, recent work is discussed that suggests that many more functional p53 pathway SNPs are yet to be fully characterized and that a thorough analysis of the functional human genetics of this important tumor suppressor pathway is required. |
| spellingShingle | Grochola, L Zeron-Medina, J Mériaux, S Bond, G Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title | Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title_full | Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title_fullStr | Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title_full_unstemmed | Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title_short | Single-nucleotide polymorphisms in the p53 signaling pathway. |
| title_sort | single nucleotide polymorphisms in the p53 signaling pathway |
| work_keys_str_mv | AT grocholal singlenucleotidepolymorphismsinthep53signalingpathway AT zeronmedinaj singlenucleotidepolymorphismsinthep53signalingpathway AT meriauxs singlenucleotidepolymorphismsinthep53signalingpathway AT bondg singlenucleotidepolymorphismsinthep53signalingpathway |