Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial

Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-escalation, randomised, controlled, phase 1 trial

<p><strong>Background:</strong>&nbsp;<em>Mycobacterium tuberculosis</em>&nbsp;is the main causative agent of tuberculosis. BCG, the only licensed vaccine, provides inadequate protection against pulmonary tuberculosis. Controlled human infection models are useful...

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Bibliographic Details
Main Authors: Satti, I, Marshall, JL, Harris, SA, Wittenberg, R, Tanner, R, Lopez Ramon, R, Wilkie, M, Ramos Lopez, F, Riste, M, Wright, D, Peralta Alvarez, MP, Williams, N, Morrison, H, Stylianou, E, Folegatti, P, Jenkin, D, Vermaak, S, Rask, L, Cabrera Puig, I, Powell Doherty, R, Lawrie, A, Moss, P, Hinks, T, Bettinson, H, McShane, H
Format: Journal article
Language:English
Published: Elsevier 2024

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