Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis

Platelet homeostasis is essential for vascular integrity and immune defence1, 2. Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by thei...

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Main Authors: Gaertner, F, Ishikawa-Ankerhold, H, Stutte, S, Fu, W, Weitz, J, Dueck, A, Nelakuditi, B, Fumagalli, V, van den Heuvel, D, Belz, L, Sobirova, G, Zhang, Z, Titova, A, Navarro, AM, Pekayvaz, K, Lorenz, M, von Baumgarten, L, Kranich, J, Straub, T, Popper, B, Zheden, V, Kaufmann, WA, Guo, C, Piontek, G, Nerlov, C
Format: Journal article
Language:English
Published: Nature Research 2024