Persistent DNA strand breaks induce a CAF-like phenotype in normal fibroblasts

Cancer-associated fibroblasts (CAFs) are an emerging target for cancer therapy as they promote tumour growth and metastatic potential. However, CAF targeting is complicated by the lack of knowledge-based strategies aiming to selectively eliminate these cells. There is a growing body of evidence sugg...

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Bibliographic Details
Main Authors: Legrand, A, Poletto, M, Pankova, D, Clementi, E, Moore, J, Castro-Giner, F, Ryan, A, O'Neill, E, Markkanen, E, Dianov, G
Format: Journal article
Language:English
Published: Impact Journals 2018