The role of the priming loop in influenza A virus RNA synthesis

The role of the priming loop in influenza A virus RNA synthesis

RNA-dependent RNA polymerases (RdRps) are used by RNA viruses to replicate and transcribe their RNA genomes1 . They adopt a closed, right-handed fold with conserved subdomains called palm, fingers and thumb1,2. Conserved RdRp motifs A–F coordinate the viral RNA template, NTPs and magnesium ions to f...

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Bibliografiske detaljer
Main Authors:	Te Velthuis, A, Robb, N, Kapanidis, A, Fodor, E
Format:	Journal article
Udgivet:	Nature 2016

Lignende værker

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af: Robb, N, et al.
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Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA
af: Robb, N, et al.
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Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter.
af: Tomescu, A, et al.
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The role of the PB2 627-domain in influenza A virus polymerase function
af: Nilsson, B, et al.
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Characterizing Influenza a RNA Polymerase - Promoter Interaction using Ensemble Fluorescence Spectroscopy
af: Tomescu, A, et al.
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Structure and function of the influenza virus transcription and replication machinery
af: Fodor, E, et al.
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The RNA-dependent RNA polymerase of the influenza A virus
af: Stubbs, T, et al.
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Influenza Virus RNA Synthesis and the Innate Immune Response
af: Sabrina Weis, et al.
Udgivet: (2021-04-01)

Uncoupling of influenza A virus transcription and replication through mutation of the unpaired adenosine in the viral RNA promoter.
af: te Velthuis, A, et al.
Udgivet: (2013)

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome
af: Robb, N, et al.
Udgivet: (2009)

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome.
af: Robb, N, et al.
Udgivet: (2009)

Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein.
af: Robb, N, et al.
Udgivet: (2010)

The role of the influenza virus RNA polymerase in host shut-off.
af: Vreede, F, et al.
Udgivet: (2010)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein
af: Robb, N, et al.
Udgivet: (2012)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
af: Robb, N, et al.
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The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication.
af: Fodor, E
Udgivet: (2013)

Decoding the Role of Temperature in RNA Virus Infections
af: Karishma Bisht, et al.
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Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities.
af: Chan, W, et al.
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Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities
af: Chan, W, et al.
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Interplay between influenza virus and the host RNA polymerase II transcriptional machinery
af: Walker, A, et al.
Udgivet: (2019)

Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II.
af: Engelhardt, O, et al.
Udgivet: (2005)

Influenza virus inhibits RNA polymerase II elongation.
af: Chan, A, et al.
Udgivet: (2006)

Characterization of the RNA-fork model of virion RNA in the initiation of transcription in influenza A virus.
af: Fodor, E, et al.
Udgivet: (1995)

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response.
af: Wang, Z, et al.
Udgivet: (2010)

NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response
af: Wang, Z, et al.
Udgivet: (2010)

Attenuation of influenza A virus mRNA levels by promoter mutations.
af: Fodor, E, et al.
Udgivet: (1998)

Insight into the multifunctional RNA synthesis machine of rabies virus
af: Fodor, E
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Closing and opening of the RNA polymerase trigger loop
af: Mazumder, A, et al.
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The surface-exposed PA51-72-loop of the influenza A virus polymerase is required for viral genome replication
af: Nilsson-Payant, B, et al.
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The PB2 subunit of the influenza A virus RNA polymerase is imported into the mitochondrial matrix
af: Long, J, et al.
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Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.
af: Deng, T, et al.
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Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses.
af: Tessa N Cressey, et al.
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Host restriction of influenza virus polymerase activity by PB2 627E is diminished on short viral templates in a nucleoprotein-independent manner.
af: Paterson, D, et al.
Udgivet: (2014)

Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo.
af: Kim, H, et al.
Udgivet: (1997)

Emerging roles for the influenza A virus nuclear export protein (NEP).
af: Paterson, D, et al.
Udgivet: (2012)

Mutation of an influenza virus polymerase 3′ RNA promoter binding site inhibits transcription elongation
af: Walker, A, et al.
Udgivet: (2020)

Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export.
af: Poon, L, et al.
Udgivet: (2000)

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af: te Velthius, AJW, et al.
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