The role of the priming loop in influenza A virus RNA synthesis

RNA-dependent RNA polymerases (RdRps) are used by RNA viruses to replicate and transcribe their RNA genomes1 . They adopt a closed, right-handed fold with conserved subdomains called palm, fingers and thumb1,2. Conserved RdRp motifs A–F coordinate the viral RNA template, NTPs and magnesium ions to f...

Description complète

Détails bibliographiques
Auteurs principaux: Te Velthuis, A, Robb, N, Kapanidis, A, Fodor, E
Format: Journal article
Publié: Nature 2016