Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy.
Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the...
Үндсэн зохиолчид: | van Maurik, A, Herber, M, Wood, K, Jones, N |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2002
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Ижил төстэй зүйлс
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Dependency of direct pathway CD4+ T cells on CD40-CD154 costimulation is determined by nature and microenvironment of primary contact with alloantigen.
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Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.
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