Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich's ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransferases, specifically SUV4-20 H1, play an importan...

Detaylı Bibliyografya
Asıl Yazarlar:	Vilema Enriquez, MG, Quinlan, R, Kilfeather, P, Mazzone, R, Saqlain, S, Del Molino Del Barrio, I, Donato, A, Corda, G, Li, F, Vedadi, M, Németh, AH, Brennan, PE, Wade-Martins, R
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	American Society for Biochemistry and Molecular Biology 2020

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