Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.

Heterologous prime-boost strategies hold promise for vaccination against tuberculosis. However, the T-cell characteristics required for protection are not known. We proposed that boost vaccines should induce long-lived functional and phenotypic changes to T cells primed by Bacille Calmette Guerin (B...

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Bibliographic Details
Main Authors: Dintwe, O, Day, C, Smit, E, Nemes, E, Gray, C, Tameris, M, Mcshane, H, Mahomed, H, Hanekom, W, Scriba, T
Format: Journal article
Language:English
Published: 2013