Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associ...

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Bibliographic Details
Main Authors:	Evans, D, Spencer, C, Pointon, J, Su, Z, Harvey, D, Kochan, G, Oppermann, U, Dilthey, A, Pirinen, M, Stone, M, Appleton, L, Moutsianas, L, Leslie, S, Wordsworth, T, Kenna, T, Karaderi, T, Thomas, G, Ward, M, Weisman, M, Farrar, C, Bradbury, L, Danoy, P, Inman, R, Maksymowych, W, Gladman, D
Format:	Journal article
Language:	English
Published:	2011

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

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