Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associ...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797083832380293120 |
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| author | Evans, D Spencer, C Pointon, J Su, Z Harvey, D Kochan, G Oppermann, U Dilthey, A Pirinen, M Stone, M Appleton, L Moutsianas, L Leslie, S Wordsworth, T Kenna, T Karaderi, T Thomas, G Ward, M Weisman, M Farrar, C Bradbury, L Danoy, P Inman, R Maksymowych, W Gladman, D |
| author_facet | Evans, D Spencer, C Pointon, J Su, Z Harvey, D Kochan, G Oppermann, U Dilthey, A Pirinen, M Stone, M Appleton, L Moutsianas, L Leslie, S Wordsworth, T Kenna, T Karaderi, T Thomas, G Ward, M Weisman, M Farrar, C Bradbury, L Danoy, P Inman, R Maksymowych, W Gladman, D |
| author_sort | Evans, D |
| collection | OXFORD |
| description | Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides. |
| first_indexed | 2024-03-07T01:47:02Z |
| format | Journal article |
| id | oxford-uuid:98c354cc-d9bb-45fc-80af-231a6fe59039 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:47:02Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:98c354cc-d9bb-45fc-80af-231a6fe590392022-03-27T00:09:23ZInteraction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:98c354cc-d9bb-45fc-80af-231a6fe59039EnglishSymplectic Elements at Oxford2011Evans, DSpencer, CPointon, JSu, ZHarvey, DKochan, GOppermann, UDilthey, APirinen, MStone, MAppleton, LMoutsianas, LLeslie, SWordsworth, TKenna, TKaraderi, TThomas, GWard, MWeisman, MFarrar, CBradbury, LDanoy, PInman, RMaksymowych, WGladman, DAnkylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides. |
| spellingShingle | Evans, D Spencer, C Pointon, J Su, Z Harvey, D Kochan, G Oppermann, U Dilthey, A Pirinen, M Stone, M Appleton, L Moutsianas, L Leslie, S Wordsworth, T Kenna, T Karaderi, T Thomas, G Ward, M Weisman, M Farrar, C Bradbury, L Danoy, P Inman, R Maksymowych, W Gladman, D Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title_full | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title_fullStr | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title_full_unstemmed | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title_short | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| title_sort | interaction between erap1 and hla b27 in ankylosing spondylitis implicates peptide handling in the mechanism for hla b27 in disease susceptibility |
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