Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

<p>Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where MiDAS reactions occur when BRCA2 is abrogated. High-resolution profiling revea...

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Autors principals:	Groelly, FJ, Dagg, RA, Petropoulos, M, Rossetti, GG, Prasad, B, Panagopoulos, A, Paulsen, T, Karamichali, A, Jones, SE, Ochs, F, Dionellis, VS, Puig Lombardi, E, Miossec, MJ, Lockstone, H, Legube, G, Blackford, AN, Altmeyer, M, Halazonetis, TD, Tarsounas, M
Format:	Journal article
Idioma:	English
Publicat:	Cell Press 2022

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