Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy
Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific treatment design. In this paper, we investigate how two different...
| Hlavní autoři: | , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
Springer
2023
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| _version_ | 1826310729859334144 |
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| author | Colson, C Maini, PK Byrne, HM |
| author_facet | Colson, C Maini, PK Byrne, HM |
| author_sort | Colson, C |
| collection | OXFORD |
| description | Cancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these
differences impact sensitivity to treatment is an essential step towards
patient-specific treatment design. In this paper, we investigate how two
different mechanisms for growth control may affect tumour cell responses
to fractionated radiotherapy (RT) by extending an existing ordinary differential equation model of tumour growth. In the absence of treatment,
this model distinguishes between growth arrest due to nutrient insufficiency and competition for space and exhibits three growth regimes:
nutrient-limited (NL), space limited (SL) and bistable (BS), where both
mechanisms for growth arrest coexist. We study the effect of RT for
tumours in each regime, finding that tumours in the SL regime typically
respond best to RT, while tumours in the BS regime typically respond
worst to RT. For tumours in each regime, we also identify the biological
processes that may explain positive and negative treatment outcomes and
the dosing regimen which maximises the reduction in tumour burden. |
| first_indexed | 2024-03-07T07:57:45Z |
| format | Journal article |
| id | oxford-uuid:99131f0d-3b83-4cf9-b3d4-7b2b6a553234 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:57:45Z |
| publishDate | 2023 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:99131f0d-3b83-4cf9-b3d4-7b2b6a5532342023-08-31T08:28:15ZInvestigating the influence of growth arrest mechanisms on tumour responses to radiotherapyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:99131f0d-3b83-4cf9-b3d4-7b2b6a553234EnglishSymplectic ElementsSpringer2023Colson, CMaini, PKByrne, HMCancer is a heterogeneous disease and tumours of the same type can differ greatly at the genetic and phenotypic levels. Understanding how these differences impact sensitivity to treatment is an essential step towards patient-specific treatment design. In this paper, we investigate how two different mechanisms for growth control may affect tumour cell responses to fractionated radiotherapy (RT) by extending an existing ordinary differential equation model of tumour growth. In the absence of treatment, this model distinguishes between growth arrest due to nutrient insufficiency and competition for space and exhibits three growth regimes: nutrient-limited (NL), space limited (SL) and bistable (BS), where both mechanisms for growth arrest coexist. We study the effect of RT for tumours in each regime, finding that tumours in the SL regime typically respond best to RT, while tumours in the BS regime typically respond worst to RT. For tumours in each regime, we also identify the biological processes that may explain positive and negative treatment outcomes and the dosing regimen which maximises the reduction in tumour burden. |
| spellingShingle | Colson, C Maini, PK Byrne, HM Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title | Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title_full | Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title_fullStr | Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title_full_unstemmed | Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title_short | Investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| title_sort | investigating the influence of growth arrest mechanisms on tumour responses to radiotherapy |
| work_keys_str_mv | AT colsonc investigatingtheinfluenceofgrowtharrestmechanismsontumourresponsestoradiotherapy AT mainipk investigatingtheinfluenceofgrowtharrestmechanismsontumourresponsestoradiotherapy AT byrnehm investigatingtheinfluenceofgrowtharrestmechanismsontumourresponsestoradiotherapy |