Randomised controlled trial of urokinase versus placebo for non-draining malignant pleural effusion

Randomised controlled trial of urokinase versus placebo for non-draining malignant pleural effusion

<h4>Rationale</h4> <p>Patients with malignant pleural effusion (MPE) experience breathlessness, which is treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and pleurodesis failure. Intrapleural fibrinolytics lyse septations within pleural fluid, i...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Mishra, E, Clive, A, Wills, G, Davies, H, Stanton, A, Al-Aloul, M, Hart-Thomas, A, Pepperell, J, Evison, M, Saba, T, Harrison, R, Guhan, A, Callister, M, Sathyamurthy, R, Rehal, S, Corcoran, J, Hallifax, R, Psallidas, I, Russell, N, Shaw, R, Dobson, M, Wrightson, J, West, A, Lee, Y, Nunn, A, Miller, R, Maskell, N, Rahman, N
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	American Thoracic Society 2018

Παρόμοια τεκμήρια

P234 Patient and fluid characteristics associated with non-draining malignant pleural effusion
ανά: Mishra, E, κ.ά.
Έκδοση: (2017)

Does talc increase risk of non-draining septated pleural effusion after indwelling pleural catheter insertion?
ανά: Asciak, R, κ.ά.
Έκδοση: (2018)

Chest drain size: the debate continues
ανά: Hallifax, R, κ.ά.
Έκδοση: (2017)

Providing safe and effective pleural medicine services in the UK: An aspirational statement from UK pleural physicians
ανά: Evison, M, κ.ά.
Έκδοση: (2018)

Chest drain rall-out rate according to suturing practices: a retrospective direct comparison
ανά: Asciak, R, κ.ά.
Έκδοση: (2018)

Does attempting talc pleurodesis affect subsequent indwelling pleural catheter (IPC)-related non-draining septated pleural effusion and IPC-related spontaneous pleurodesis?
ανά: Asciak, R, κ.ά.
Έκδοση: (2019)

Retrospective analysis of survival time in malignant pleural effusion requiring IPC insertion
ανά: Asciak, R, κ.ά.
Έκδοση: (2017)

Is a pleural on-call service beneficial?
ανά: Asciak, R, κ.ά.
Έκδοση: (2017)

Activity and outcomes from a dedicated pleural on-call service
ανά: Asciak, R, κ.ά.
Έκδοση: (2018)

S128 Exploring the behaviour of mesothelioma in a post hoc analysis from the time 1 trial
ανά: Mercer, R, κ.ά.
Έκδοση: (2017)

Predictors of pleurodesis success
ανά: Mercer, R, κ.ά.
Έκδοση: (2018)

Does inflammation predict successful pleurodesis? A post hoc analysis from the time 1 trial
ανά: Mercer, R, κ.ά.
Έκδοση: (2017)

Breathlessness post-drainage predicts survival in patients with malignant pleural effusion
ανά: Mishra, E, κ.ά.
Έκδοση: (2018)

Response
ανά: Wrightson, J, κ.ά.
Έκδοση: (2010)

Pseudochylothorax without pleural thickening: time to reconsider pathogenesis?
ανά: Wrightson, J, κ.ά.
Έκδοση: (2009)

EFFUSION SIZE ON THE CHEST RADIOGRAPH AT DAY 7 POST-PLEURAL DRAINAGE IS A GOOD PREDICTOR OF SIZE AT 3 MONTHS, REGARDLESS OF INITIAL INTRAPLEURAL THERAPY
ανά: Hallifax, R, κ.ά.
Έκδοση: (2012)

Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial.
ανά: Rahman, N, κ.ά.
Έκδοση: (2015)

Medical thoracoscopy: Survey of current practice—How successful are medical thoracoscopists at predicting malignancy?
ανά: Hallifax, R, κ.ά.
Έκδοση: (2015)

Pleural diseases: saline irrigation in pleural infection, epidemiology of pneumothorax, and bevacizumab in mesothelioma
ανά: Corcoran, J, κ.ά.
Έκδοση: (2017)

Image of the month: A misleading chest X-ray - not all opacification is effusion.
ανά: Psallidas, I, κ.ά.
Έκδοση: (2014)

Tips and tricks in the management of pneumothorax: An update
ανά: Hassan, M, κ.ά.
Έκδοση: (2017)

Prospective nalysis of the predictive value of sonographic pleural fluid echogenicity for the diagnosis of exudative effusion
ανά: Asciak, R, κ.ά.
Έκδοση: (2019)

Clinically important associations of pleurodesis success in malignant pleural effusion: Analysis of the TIME1 data set
ανά: Mercer, RM, κ.ά.
Έκδοση: (2019)

Response
ανά: Wrightson, J, κ.ά.
Έκδοση: (2010)

The biological effect of intrapleural tissue plasminogen (tPA) activator and DNase delivery in pleural infection patients
ανά: Kanellakis, N, κ.ά.
Έκδοση: (2018)

Survival and pleurodesis outcome in patients with malignant pleural effusion – post-hoc analysis from the TIME-1 trial
ανά: Hassan, M, κ.ά.
Έκδοση: (2018)

Effectiveness of chemical pleurodesis in spontaneous pneumothorax recurrence prevention: a systematic review.
ανά: Hallifax, R, κ.ά.
Έκδοση: (2016)

Thoracic ultrasonography as a predictor of pleurodesis success in malignant pleural effusion
ανά: Corcoran, J, κ.ά.
Έκδοση: (2017)

The hospital and patient burden of indwelling pleural catheters: A retrospective case series of 210 indwelling pleural catheter insertions
ανά: Asciak, R, κ.ά.
Έκδοση: (2018)

P210 Defining the minimal important difference for the visual analogue scale for dyspnoea in patients with malignant pleural effusions
ανά: Mishra, E, κ.ά.
Έκδοση: (2013)

Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.
ανά: Mishra, E, κ.ά.
Έκδοση: (2015)

Tuberculous pleuritis secondary to Mycobacterium bovis in a veterinarian.
ανά: Corcoran, J, κ.ά.
Έκδοση: (2014)

Biological markers of successful pleurodesis for malignant pleural effusion
ανά: Psallidas, I, κ.ά.
Έκδοση: (2016)

Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.
ανά: Kapustin, A, κ.ά.
Έκδοση: (2012)

The biological effect of tissue plasminogen (t-PA) activator and DNase intrapleural delivery in pleural infection patients
ανά: Kanellakis, N, κ.ά.
Έκδοση: (2018)

Thoracic ultrasound as an early predictor of pleurodesis success in malignant pleural effusion
ανά: Corcoran, J, κ.ά.
Έκδοση: (2018)

Assessment of patient-reported outcome measures in pleural interventions
ανά: Psallidas, I, κ.ά.
Έκδοση: (2017)

Reexpansion pulmonary edema following local anesthetic thoracoscopy: correlation and evolution of radiographic and ultrasonographic findings.
ανά: Corcoran, J, κ.ά.
Έκδοση: (2014)

Seldinger chest drain insertion: simpler but not necessarily safer.
ανά: Maskell, N, κ.ά.
Έκδοση: (2010)

Late Breaking Abstract - A phase I feasibility study in establishing the role of ultrasound-guided pleural biopsies in pleural infection (The AUDIO study)
ανά: Psallidas, I, κ.ά.
Έκδοση: (2017)