A second-generation total synthesis of spirastrellolide A methyl ester.
Marine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797083933560537088 |
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| author | Paterson, I Maltas, P Dalby, S Lim, J Anderson, E |
| author_facet | Paterson, I Maltas, P Dalby, S Lim, J Anderson, E |
| author_sort | Paterson, I |
| collection | OXFORD |
| description | Marine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region. |
| first_indexed | 2024-03-07T01:48:32Z |
| format | Journal article |
| id | oxford-uuid:9944450d-327e-48ad-814b-6dd315dd41aa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:48:32Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:9944450d-327e-48ad-814b-6dd315dd41aa2022-03-27T00:13:06ZA second-generation total synthesis of spirastrellolide A methyl ester.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9944450d-327e-48ad-814b-6dd315dd41aaEnglishSymplectic Elements at Oxford2012Paterson, IMaltas, PDalby, SLim, JAnderson, EMarine macrolides: an improved second-generation total synthesis of the anticancer macrolide spirastrellolide A methyl ester has been achieved. The synthesis features a uniformly high level of stereocontrol combined with more expedient fragment assembly, and demonstrates a critical dependence of the crucial macrolactonization step on the substitution pattern of the C22-C24 linker region. |
| spellingShingle | Paterson, I Maltas, P Dalby, S Lim, J Anderson, E A second-generation total synthesis of spirastrellolide A methyl ester. |
| title | A second-generation total synthesis of spirastrellolide A methyl ester. |
| title_full | A second-generation total synthesis of spirastrellolide A methyl ester. |
| title_fullStr | A second-generation total synthesis of spirastrellolide A methyl ester. |
| title_full_unstemmed | A second-generation total synthesis of spirastrellolide A methyl ester. |
| title_short | A second-generation total synthesis of spirastrellolide A methyl ester. |
| title_sort | second generation total synthesis of spirastrellolide a methyl ester |
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