Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release
Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves both membrane potential-dependent and -independent pathways. Alth...
Main Authors: | Denwood, G, Tarasov, A, Salehi, A, Vergari, E, Ramracheya, R, Takahashi, H, Nikolaev, V, Seino, S, Gribble, F, Reimann, F, Rorsman, P, Zhang, Q |
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Format: | Journal article |
Language: | English |
Published: |
Rockefeller University Press
2019
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